In Activated Murine Mast Cells, NFATc2 Is Critical for the Production of Autocrine IL-3, Thereby Promoting the Expression of IL-9

Abstract IL-9 has lent its numerical designation to the Th9 subset of CD4+ Th cells, although it is also produced by additional cell types, including mast cells. It a pleiotropic cytokine involved in allergic reactions, parasitic infections, autoimmune inflammation, and cancer immunity. In this article, we provide evidence that NFATc2 contradictory functions expression murine cells bone marrow–derived (BMMC). The basis for our observation production NFATc2-deficient increased, whereas decreased BMMC devoid NFATc2. addition, deficiency almost completely abrogates IL-3 both types. However, selectively BMMC, critically depends on autocrine acting via sustained activation STAT5 IL-9. Furthermore, demonstrate acts independently synergistically with IL-1β Taken together, highlight NFATc2-driven as critical type–specific component BMMC.